Tag: Linda Wilbrecht
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Ronald E. Dahl, Nicholas B. Allen, Linda Wilbrecht & Ahna Ballonoff Suleiman, Importance of investing in adolescence from a developmental science perspective, Nature (v 554) pp. 441–450 (Feb. 2018), doi:10.1038/nature25770
Dahl, R., Allen, N., Wilbrecht, L. et al. Importance of investing in adolescence from a developmental science perspective. Nature 554, 441–450 (2018). https://doi-org.libproxy.berkeley.edu/10.1038/nature25770
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Josiah R. Boivin, David J. Piekarski, Jessica K. Wahlberg, Linda Wilbrecht, Age, sex, and gonadal hormones differently influence anxiety- and depression-related behavior during puberty in mice, Psychoneuroendocrinology,Volume 85, 2017, Pages 78-87, ISSN 0306-4530, https://doi.org/10.1016/j.psyneuen.2017.08.009
Josiah R. Boivin, David J. Piekarski, Jessica K. Wahlberg, Linda Wilbrecht,
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Ovarian Hormones Organize the Maturation of Inhibitory Neurotransmission in the Frontal Cortex at Puberty Onset in Female Mice
The frontal cortex matures late in development, showing dramatic changes after puberty onset, yet few experiments have directly tested the role of pubertal hormones in cortical maturation. One mechanism thought to play a primary role in regulating the maturation of the neocortex is an increase in inhibitory neurotransmission, which alters the balance of excitation and…
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Faculty Forum: Characterizing Effects of Inequality on Brain Development & Strengthening Resilience against Adversity
UC Berkeley’s Vice Chancellor for Research is holding a faculty forum on Characterizing Effects of Inequality on Brain Development & Strengthening Resilience against Adversity on Tuesday, October 4th at the Faculty Club. The event is convened by Linda Wilbrecht, Silvia Bunge, Daniela Kaufer, Julianna Deardorff, and Lance Kriegsfeld .
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Wilbrecht in Conversation with Tom Stoppard and Carey Perloff
On Monday, October 3rd, Linda Wilbrecht will join Tom Stoppard and Carey Perloff in conversation at the ACT Theater. Tom Stoppard and Carey Perloff—In Conversation Monday, October 3, 7 p.m. A.C.T.’s Geary Theater Tony, Academy, and Olivier Award winner Tom Stoppard will join A.C.T. Artistic Director Carey Perloff “In Conversation” at The Geary Theater where…
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Lung-Hao Tai’s collaborative work with Bo Li lab recently published
Lung-Hao Tai’s collaborative work with the Bo Li lab was recently published as: Marcus Stephenson-Jones, Kai Yu, Sandra Ahrens, Jason M. Tucciarone, Aile N. van Huijstee, Luis A. Mejia, Mario A. Penzo, Lung-Hao Tai, Linda Wilbrecht, Bo Li, A basal ganglia circuit for evaluating action outcomes, Nature, http://dx.doi.org/10.1038/nature19845 (2016).
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Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Postnatal brain development is studded with sensitive periods during which experience dependent plasticity is enhanced. This enables rapid learning from environmental inputs and reorganization of cortical circuits that matches behavior with environmental contingencies. Significant headway has been achieved in characterizing and understanding sensitive period biology in primary sensory cortices, but relatively little is known about…
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Long-range orbitofrontal and amygdala axons show divergent patterns of maturation in the frontal cortex across adolescence
The adolescent transition from juvenile to adult is marked by anatomical and functional remodeling of brain networks. Currently, the cellular and synaptic level changes underlying the adolescent transition are only coarsely understood. Here, we use two-photon imaging to make time-lapse observations of long-range axons that innervate the frontal cortex in the living brain. We labeled…
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Rule learning enhances structural plasticity of long range axons in frontal cortex
Rules encompass cue-action-outcome associations used to guide decisions and strategies in a specific context. Subregions of the frontal cortex including the orbitofrontal cortex (OFC) and dorsomedial prefrontal cortex (dmPFC) are implicated in rule learning, although changes in structural connectivity underlying rule learning are poorly understood. We imaged OFC axonal projections to dmPFC during training in…
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Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia
The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a brainstem target of BG that is critical for locomotion. We optogenetically dissect…