The Rockefeller University hosted John Coates and Linda Wilbrecht for a discussion moderated by Marc Tessier-Lavigne. The group focused upon the biological regulation of risk-taking behavior, addressing how experience can alter future behavior, and how age, developmental critical periods, and gender can affect decision making. The group also discussed Coates’ recent book, The Hour Between Dog and Wolf: Risk Taking, Gut Feelings and the Biology of Boom and Bust.