Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent

The maturation of inhibitory circuits during adolescence may be tied to the onset of mental health disorders such as schizophrenia. Neurotrophin signaling likely plays a critical role in supporting inhibitory circuit development and is also implicated in psychiatric disease. Within the neocortex, subcircuits may mature at different times and show differential sensitivity to neurotrophin signaling. We measured miniature inhibitory and excitatory postsynaptic currents (mIPSCs and mEPSCs) in Layer 5 cell-types in the mouse anterior cingulate (Cg) across the periadolescent period. We differentiated cell-types mainly by Thy1 YFP transgene expression and also retrobead injection labeling in the contralateral Cg and ipsilateral pons. We found that YFP− neurons and commissural projecting neurons had lower frequency of mIPSCs than neighboring YFP+ neurons or pons projecting neurons in juvenile mice (P21–25). YFP− neurons and to a lesser extent commissural projecting neurons also showed a significant increase in mIPSC amplitude during the periadolescent period (P21–25 vs. P40–50), which was not seen in YFP+ neurons or pons projecting neurons. Systemic disruption of tyrosine kinase receptor B (TrkB) signaling during P23–50 in TrkBF616A mice blocked developmental changes in mIPSC amplitude, without affecting miniature excitatory post synaptic currents (mEPSCs). Our data suggest that the maturation of inhibitory inputs onto Layer 5 pyramidal neurons is cell-type specific. These data may inform our understanding of adolescent brain development across species and aid in identifying candidate subcircuits that may show greater vulnerability in mental illness.

Vandenberg A, Piekarski DJ, Caporale N, Munoz-Cuevas FJ and Wilbrecht L (2015) Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent. Front. Neural Circuits 9:5. doi: 10.3389/fncir.2015.00005

Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent2015-02-17T12:10:30+00:00

Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference

Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spines, and that measures of new persistent spine gain correlated with cocaine conditioned place preference. Our data suggest that new persistent spine formation in the frontal cortex may be involved in stimulant-related learning driving appetitive behavior.

Francisco Javier Muñoz-Cuevas, Jegath Athilingam, Denise Piscopo, Linda Wilbrecht, Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference, Nature Neuroscience (2013) doi:10.1038/nn.3498 (Full Text)

Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference2013-08-25T16:33:52+00:00

extreme weight loss diet pills does fish oil pills help you lose weight red weight loss pills medicines for weight loss blake shelton weight loss diet gluten free vegan diet plan for weight loss what is the best weight loss pill for me daily weight loss diet plan buy keto weight loss pills weight loss diets for teenage girls pills blake shelton took for weight loss best weight loss diet women beautiful slim body weight loss pills nutri shoppe weight loss pills weight loss pills not fda approved does my insurance cover weight loss pills pescatarian diet and weight loss mens health weight loss diet 500lb weight loss diet weight loss pills start with q most effective weight loss diet review melissa mccarthy weight loss diet pills pills to lose weight and not work out are there any pills that make you lose weight

penis enlargement products accidental penis enlargement natural male enhancement foods herbs gnc enhancement pills top male enhancement at gnc growth pills for penis blue pill a 17 best ed otc pills penis enlargement talisman maca pills passion are they to inhanse sex penis enlargement horror stories catholic answers male enhancement pills nutrients for natural penis enlargement 1 selling male enhancement male enhancement before sex best penis enlargement supplements can both control pills affect sex drive male vitality enhancement excel sex pills samurai x pill reviews blood pressure otc drugs penis enlargement jel 1xd supplement reviews what are happy pills called

gold drops cbd dr cbd hemp full spectrum cbd shirt cbd and drug testing cbd oil or cream for pain cbd oil dossage va and cbd oil cbd oil depression reddit do you get high off of cbd oil cbd oil for wrinkles before and after expedia hotels sydney cbd montel williams cbd using cbd to treat anxiety what is a good dose of cbd cbd lotion cvs cbd placebo what can cbd oil do cbd oil for cyclic vomiting syndrome insomnia cbd oil topical cbd oil skin cancer green roads tea with cbd oil cbd oil adrenaline does aleve interact with cbd oil is cbd oil legal in il