Tag: David Piekarski
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Josiah R. Boivin, David J. Piekarski, Jessica K. Wahlberg, Linda Wilbrecht, Age, sex, and gonadal hormones differently influence anxiety- and depression-related behavior during puberty in mice, Psychoneuroendocrinology,Volume 85, 2017, Pages 78-87, ISSN 0306-4530, https://doi.org/10.1016/j.psyneuen.2017.08.009
Josiah R. Boivin, David J. Piekarski, Jessica K. Wahlberg, Linda Wilbrecht,
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Ovarian Hormones Organize the Maturation of Inhibitory Neurotransmission in the Frontal Cortex at Puberty Onset in Female Mice
The frontal cortex matures late in development, showing dramatic changes after puberty onset, yet few experiments have directly tested the role of pubertal hormones in cortical maturation. One mechanism thought to play a primary role in regulating the maturation of the neocortex is an increase in inhibitory neurotransmission, which alters the balance of excitation and…
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New Paper by Piekarski & Boivin
David Piekarski and Josiah Boivin have a new paper published in Current Biology that shows organizational effects of ovarian hormones on the maturation of inhibitory neurotransmission in the mouse frontal cortex during puberty.
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Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Postnatal brain development is studded with sensitive periods during which experience dependent plasticity is enhanced. This enables rapid learning from environmental inputs and reorganization of cortical circuits that matches behavior with environmental contingencies. Significant headway has been achieved in characterizing and understanding sensitive period biology in primary sensory cortices, but relatively little is known about…
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David Piekarski Receives New Investigator Award at SBN
David Piekarski was recently granted the New Investigator Award at the 2016 Society for Behavioral Neuroendocrinology (SBN) meeting in Montreal.
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Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent
The maturation of inhibitory circuits during adolescence may be tied to the onset of mental health disorders such as schizophrenia. Neurotrophin signaling likely plays a critical role in supporting inhibitory circuit development and is also implicated in psychiatric disease. Within the neocortex, subcircuits may mature at different times and show differential sensitivity to neurotrophin signaling.…